- Herbert Garrison: The main teacher for the 3rd Grade. He was promoted to a higher pay to work as the 4th grade teacher.
- Mrs. O'Donnell: After Mr. Garrison was fired for something the boys did, Mrs. O'Donnell came as a substitute teacher. He was later to be revealed a serial killer in "An Evil Teacher".
- Mr. Mackey: Substitute after Mr. Garrison was fired.
- Mr. Slave: Mr. Garrison's teaching assistant From The Death Camp of Tolerance to sometime before South Park is Gay!
- Mrs. Dreibel: Teaches art in hr own classroom during Toilet Paper
- Richard Dawkins: Teaches evolutionary studies.
- Mr. Adler: Teaches shop class.
- Pearl: Teaches Home Ec.
- Darius Prince: Teaches Physical Education.
Students in this section are seen in Mr. Garrison's fifth grade classroom in almost all episodes
- Annie Faulk
- Bebe Stevens
- Bradley Biggle
- Butters Stotch
- Clyde Donovan
- Craig Tucker
- Eric Cartman
- Hayley Wealth
- Jeffrey Smith
- Jenny Grave
- Jerry Cartman
- Juan Garcia
- Kenny McCormick
- Kyle Broflovski
- Mark Ranson
- Shane Marks
- Stan Marsh
- Token Black
- Wendy Testaburger
Students in this section are seen in Mr. Garrison's fifth grade classroom but only in some episodes
- Heidi Turner
- Jimmy Valmer
- Joey Wessman
- Keillor Fachiney
- Kevin Stoley
- Laurie Cunningham
- Sally Turner
- Tom Wyatt
- Tweek Tweak
In 5th Grade (but not in Mr. Garrisons Class)Edit
Students who have not been seen in Mr. Garrison's fourth/fifth grade class but are fifth graders.
- Brad Dixon (was in Third Grade class)
- Damien (was in Third Grade class)
- Daniel Thompson (was in Fourth Grade class)
- Dogpoo Petuski (was in Third Grade class)
- Mark and Rebecca Cotswolds (was in Third Grade class)
- Terrance Mephesto (was in Third Grade class)
- Bill and Fosse (were in Third Grade class)
- Adam Conners
- Georgia Roffwell
- Tommy Turner
Students who used to appear, but have since vanished without explanation, moved away, moved school or died.